Grape Seed Extract May Help Crohn’s
Posted by Dave on Aug 9, 2012
I’ve mentioned many times on this blog that a hormone called tumor necrosis factor in the guts of Crohn’s sufferers prevents the inflammation and ulcers from healing. There are a number of drugs that reduce the TNF in the guts of Crohn’s sufferers, such as Remicade, Humira, Cimzia and steroids. But, most CD sufferers don’t realize they can also use supplements to help reduce the TNF further and accelerate healing. Here’s just one study about Grape Seed Extract.
BACKGROUND: Inflammation has played a key role in the causation of atherosclerosis. However, the effects of grape seed extract (GSE) on the pro-inflammatory intracellular signaling, enzyme activity, and inflammatory mediators of endothelial cells have not been sufficiently studied, and less information exists on the comparison between GSE and vitamin C, a well-known antioxidant compound, on their anti-inflammatory properties.
PURPOSE: We investigated the effects of GSE and vitamin C on the cell viability, oxidative stress, monocyte adhesion, the expression of nuclear factor-κB inhibitor (IκB), intercellular adhesion molecule-1 (ICAM-1) and cyclooxygenase-2 (COX-2), and the production of prostaglandin E(2) (PG E(2)) in TNF-α-treated human umbilical vein endothelial cells (HUVECs).
METHODS: Cell viability was measured by MTT assay. The adhesion of THP-1 to HUVECs was evaluated by cell adhesion assay. The oxidized nucleoside 8-hydroxydeoxyguanosine (8-OHdG) (an indicator of oxidative damage to DNA), ICAM-1, and PG E(2) were measured by ELISA. IκB and COX-2 expression were evaluated by western
blot analysis.RESULTS: TNF-α (10, 20, and 50 ng/mL), GSE (50 and 200 μg/mL), or vitamin C (100 μM) did not affect cell viability. GSE (50-100 μg/mL) attenuated TNF-α (20 ng/mL)-induced 8-OHdG production, THP-1 adhesion, the expression of IκB degradation, ICAM-1 and COX-2, and the production of PGE(2) in a dose-dependent manner. Vitamin C (100 μM) also showed significant antioxidative and anti-inflammatory effects.
CONCLUSIONS: GSE effectively ameliorates TNF-α-induced inflammatory status of HUVECs. The findings of the present study suggest that consumption of GSE may be beneficial to inflammatory atherosclerosis.
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I have been diagnosed with Diverticulitis ….I was diagnosed many years ago with IBS….the doctors are now saying they don’t think I have ever had IBS….do they think then that I have had Diverticulitis all the time then? They don’t seem to give me a concrete answer!!!!
I’ve been through seven GI doctors and each one gives me a different answer. I would most definitely suggest getting a second, or even third opinion. Don’t take the word of one doctor. They are not perfect and sometimes they just don’t know.
My husband has crohns & the first doctor who diagnosed him with it told us that his diet had no effect on crohns, which totally confused us, but have since found out that it does, so I’d listen to Toni & def get a 2nd opinion Gaye hawnt… Good luck! But we still dnt know exactly was causes a flare up in my husband & still learning all the time!
It would be cool to see a peer reviewed study looking at all the things we believe are blockers of TNF. CCFA should fund such a study since it would benefit Crohn’s patients.